We recently spoke at one of f8's breakout session about Flux, a data flow architecture that works well with React. Check out the video here:
To summarize, Flux works well for us because the single directional data flow makes it easy to understand and modify an application as it becomes more complicated. We found that two-way data bindings lead to cascading updates, where changing one data model led to another data model updating, making it very difficult to predict what would change as the result of a single user interaction.
In Flux, the Dispatcher is a singleton that directs the flow of data and ensures that updates do not cascade. As an application grows, the Dispatcher becomes more vital, as it can also manage dependencies between stores by invoking the registered callbacks in a specific order.
Flux is more of a pattern than a formal framework, so you can start using Flux immediately without a lot of new code. An example of this architecture is available, along with more detailed documentation and a tutorial. Look for more examples to come in the future.